the higher response of vascular endothelial growth factor and angiotensin-ii to human chorionic gonadotropin in women with polycystic ovary syndrome
نویسندگان
چکیده
background: this research investigated the response of vascular active factors, vascular endothelial growth factor (vegf) and angiotensin-ii (at-ii) to ovarian stimulation during 24 hours in patients with polycystic ovary syndrome (pcos). materials and methods: in this clinical trial study, 52 patients with pcos and 8 control cases were stimulated with human chorionic gonadotropin (hcg) on the 4th to 7th day of the patients’ natural or induced menstrual cycles. we measured vegf and at-ii by radioimmunoassay before the injection (0 hour) and 3, 8, 12, 18 and 24 hours after the stimulation. results: after ovarian stimulation, there was substantially higher level of vegf in typical pcos patients than the other three groups at the 3 hour time point (p<0.05), while there were no significant differences in vegf at all the other time points among the four groups. as for at-ii, before and at all time points after the ovarian stimulation, it seemed that the at-ii levels in patients’ sera with different phenotypes of pcos by the rotterdam criteria were all higher than in the control group although the differences were not statistically significant. the level of at-ii in typical pcos patients was also significantly higher than the other three groups at the 3 hour time point (p<0.05), while no significant differences at all the other time points among the four groups were observed. conclusion: the response to the stimulation varied among patients with different phenotypes of pcos according to the rotterdam criteria. serum vegf and at-ii were possible contributors to an increased risk of developing ovarian hyperstimulation syndrome (ohss) in patients with typical pcos during the early follicular phase (3 hours) after ovarian stimulation (registration number: nct02265861).
منابع مشابه
The Higher Response of Vascular Endothelial Growth Factor and Angiotensin-II to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome
Background This research investigated the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-II (AT-II) to ovarian stimulation during 24 hours in patients with polycystic ovary syndrome (PCOS). MaterialsAndMethods In this clinical trial study, 52 patients with PCOS and 8 control cases were stimulated with human chorionic gonadotropin (HCG) on the 4th ...
متن کاملThe Higher Response of Vascular Endothelial Growth Factor and Angiotensin-II to Human Chorionic Gonadotropin in Women with Polycystic Ovary Syndrome
BACKGROUND This research investigated the response of vascular active factors, vascular endothelial growth factor (VEGF) and angiotensin-II (AT-II) to ovarian stimulation during 24 hours in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS In this clinical trial study, 52 patients with PCOS and 8 control cases were stimulated with human chorionic gonadotropin (HCG) on the ...
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Lack of Serum anti-Mullerian hormone responses after recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome.
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متن کاملHuman chorionic gonadotropin-induced ovarian hyperstimulation syndrome is associated with up-regulation of vascular endothelial growth factor.
Ovarian hyperstimulation syndrome (OHSS), a life-threatening complication occurring in stimulated ovarian cycles, arises from treatment with gonadotropin for induction of follicular maturation in infertile women. Clinical characteristics of OHSS include ascites and pleural effusion induced by increased vascular permeability, where vascular endothelial growth factor (VEGF) was suspected to be th...
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Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age which can cause many problems such as hyperandrogenic symptoms and fertility problems. Objective: The present study aimed to determine the relationship of mindfulness with hyperandrogenic symptoms and demographic and fertility factors in women with PCOS. Methods: This descriptive co...
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عنوان ژورنال:
international journal of fertility and sterilityجلد ۸، شماره ۴، صفحات ۳۷۳-۳۷۸
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